This manual refers to different standards and regulatory practices from different regions and countries worldwide noting that each region and each country has its own specificities. It is intended to be used as a guiding tool for telecommunication national regulatory agencies (NRAs) or government ministries in charge of QoS and QoE (quality of experience) parameters and measurements as defined by ITU-T, as well as enforcement mechanisms. It extends ITU regulation guidelines further by introducing more hands-on information regarding the QoS and QoE big picture, as well as outlining practical approaches in QoS regulation for telecommunication/ICT services. It puts forth the case that NRAs should have the appropriate skill-set to carry out QoS regulation, and how continuous capacity building is key to adapting to market and regulatory changes. NRAs can benefit greatly by learning from each other. The argument for cooperation between regulators is strong, bringing substantive benefits through the sharing of good practice and mutual learning.