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_a10.2760/9951235 _qDOI |
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_aClemens, Witter _eautor _910548 |
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_a2025 SKIG Report _b: 2025 Report of the Society for the Advancement of AOPs Knowledgebase Interest Group _c/ Wittwehr, C., Alb, M., Audouze, K., Clerbaux, L.-A., Hench, V., Jeliazkova, N., Lin, J., Morgan, H., Mortensen, H.,Ostaszewski, M., Pollesch, N., Schaffert, A., Serra, A., Sewald, K., Tanabe, S., Tao, R., Tropsha, A., Tucker, N.,Villeneuve, D., Wiklund, L. |
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_aBruselas _b: Publications Office of the European Union _c2026 |
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_a64 páginas _b, 1 documento PDF |
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_2isbdcontent _atexto (visual) |
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_2isbdmedia _aelectrónico |
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_2rdacarrier _arecurso en línea |
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| 500 | _aSome content was created using ChapGPT 5.2.All pictures were provided by the respective authors. | ||
| 520 | 3 | _aThe Society for the Advancement of AOPs Knowledgebase Interest Group (SKIG) is an international, community-driven forum dedicated to advancing the Adverse Outcome Pathway (AOP) framework and its central implementation platform, the AOP-Wiki. Comprising more than 70 experts from regulatory agencies, academia, and research organisations worldwide, SKIG operates through regular online meetings that combine focused technical presentations with open, in-depth discussion. In 2025, SKIG addressed a wide and evolving range of topics central to the maturation of the AOP framework. These included the harmonisation of Key Events through ontology-based approaches; the development and use of AOP networks, including immune-related, inflammation-driven, and disease-oriented networks; the integration of omics and toxicogenomics data into AOP-based reasoning; quantitative and time-informed AOP development; effect biomarkers and their role in regulatory decision-making; and systematic, data-driven strategies for constructing and evaluating AOPs. In parallel, several contributions explored computational and methodological advances such as knowledge graph mining, semantic analysis, automated quality assessment of emergent AOPs, and the responsible use of artificial intelligence under expert oversight and within established AOP principles to support evidence synthesis and Key Event Relationship development. Updates on tools, standards, and governance-related initiatives further highlighted ongoing, preparatory efforts to improve the FAIRness, interoperability, usability, and future readiness of the AOP-Wiki, including foundational work informing its longer-term evolution. This breadth of topics reflects the diversity of the SKIG audience, spanning scientists, regulators, and policymakers, and underscores the group’s role as a cross-disciplinary meeting point where emerging concepts can be critically examined before broader adoption. The thematic organisation of this report allows readers to engage directly with subjects of particular relevance rather than following a strictly chronological sequence of meetings. By documenting the SKIG meetings held in 2025, the report captures both the current state and the forward trajectory of the group, which will continue its activities in 2026 and beyond. Through its sustained focus on methodological clarity, practical implementation, and community-driven innovation, SKIG contributes directly to the development and application of AOPs in support of the European Union’s policy on the protection of animals used for scientific purposes (Directive 2010/63/EU) and the European Commission’s Roadmap towards phasing out animal testing for chemical safety assessments. | |
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_95186 _aInnovación |
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_95609 _aTransformación digital |
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_99563 _aEconomía |
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_94348 _aInteligencia Artificial |
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_98654 _aPolíticas públicas |
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_98525 _aDatos |
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_99065 _aProductividad |
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_910549 _aAlb, Miriam _eautor |
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_910550 _aAudoze, Karine _eautor |
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_910551 _aClerbaux, Laure-Alix _eautor |
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_aHench, Virginia _eautor _910554 |
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_aJeliazkova, Nina _eautor _910555 |
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_aLin, Julie _eautor _910556 |
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_aMorgan, Hannah _eautor _910557 |
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_aMortensen, Holly _eautor _910558 |
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_aOSTASZEWSKI, Marek _eautor _910559 |
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_uhttps://publications.jrc.ec.europa.eu/repository/handle/JRC144096 _x0 _yAcceso a publicación |
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